Modafinil – Ultimate Truth: About So Called “Smart Drug”

Last Updated On: Dec 8, 2018 @ 9:34 am

Modafinil is a greatly amazing nootropic, in any case, it is as often as possible utilized in nootropic mixes, known as “stacks,” to upgrade its belongings significantly further. Research has demonstrated an expansion in the subjective capacities, effectiveness, and profitability of people.

Modafinil is utilized by students, workers, representatives and each one of the individuals who are keen on expanding mental performance. There is developing discussion on the utilization of medications that advance intellectual improvement.

Amphetamine-like medications have been utilized as psychological enhancers, yet they indicate imperative reactions and actuate dependence. Modafinil is a waking medication recommended to narcolepsy patients, however its utilization among sound people is expanding to improve their sharpness or to relieve weakness.
  • 1
    Enhanced mood and alertness
  • 2
    Increased motivation
  • 3
    Improved reaction time
  • 4
    Reduced fatigue
  • 5
    Better memory
Modafinil (Provigil), a drug on the market since 1997, is employed for the treatment of narcolepsy and other sleep disorders. Modafinil is known to have less or no unfriendly impacts than those found in conventional psychostimulants, for example, amphetamine, methylphenidate or cocaine.

It very well may be connected as an enemy of maniacal or hostile to exhaustion operator. Be that as it may, the waking instrument of modafinil is yet to be completely uncovered. Late investigations detailed that modafinil might be liable to manhandle and compulsion. What's more drawn out restlessness prompts pressure reactions and weakens insusceptible capacity. It was produced initially for narcolepsy patients, however is currently utilized for fixation and core interest.

It is utilized for improved concentration and consideration, decreasing mental weakness, learning capacity, Adderall elective, state of mind enhancer.
Modafinil is used in many armies of the world, in the Air Force and the US regular army, special services and rapid reaction units, military intelligence, as a drug that enhances the attention and performance of pilots, operatives and soldiers of combat units.
The previously used drug amphetamine group Dexedrin, had significant side effects:
- anger,
- nervousness,
- tremor,
- a feeling of powerlessness.

Trained fighters say that modafinil allows you to last for 40 hours without sleep, while maintaining the ability to maximize the effectiveness of action and make decisions.

Characteristics of Modafinil:

Also Known As

ProvigilModiodal, Alertec

Type

Stimulant

Good for

Energy, Focus, Learning, Memory, Motivation, Physical Performance

Stacks Well With

Acetyl-L-Carnitine,  Aniracetam, Noopept, Phenylpiracetam

Typical Dose

50–200 mg

Half-life

15 hours
Source: CNN

Summary:

Modafinil is a ground-breaking stimulant and alertness advancing medication that was created for the treatment of narcolepsy and other daytime rest issue. Be that as it may, its capacity to counteract lethargy and weariness is just piece of the image; broad testing has demonstrated that modafinil offers a great rundown of intellectual advantages going from upgraded state of mind and mental readiness to expanded inspiration, enhanced response time, lessened exhaustion, and better memory.

Modafinil is recorded as a Schedule IV controlled substance in the US and is sold as a physician recommended sedate in the US and Canada, where it is commonly endorsed under the names Provigil and Alertec. Be that as it may, its demonstrated subjective advantages likewise make it an intense and progressively mainstream nootropic or “shrewd medication” utilized off-name by understudies, agents, move specialists, and other people who are occupied with expanding alertness and upgrading mental execution.

It was developed by French scientist Michel Jouvet and Lafon Laboratories (now known as ” Chephalon “) and was found to be more effective than amphetamine in that it does not cause side effects such as anxiety disorders or repetitive behaviors.
It turned out that adrafinil in the liver is converted to modafinil , which makes the liver very stressed. In addition, three times as much adrafinil as modafinil is needed to produce an equivalent dose.
 
In spite of the fact that the impacts of modafinil are like those of amphetamines like Adderall, it’s an altogether different substance. Modafinil is an eugeroic that particularly enhances readiness, while Adderall and different amphetamines are psychostimulants that deliver an impermanent increment in generally speaking psychomotor action. Since modafinil’s activities are more focused on and particular, is thought to give a “smoother,” less jumpy vitality, have less genuine reactions, and be better endured and have a lower potential for maltreatment or enslavement than Adderall.
In fact, modafinil is considered an “alertness operator” as opposed to a stimulant, yet numerous in the nootropics network utilize it as an amazing apparatus for fixation and core interest. It is viewed as one of the more celebrated and intensely devoured nootropics, which has spread into Silicon Valley business person circles, Wall Street dealers, and an assortment of other superior people. Grown at first as a treatment for narcolepsy, Modafinil positively affects cognizance and psychological capacities while likewise enhancing fixation and core interest. Researchers estimate that modafinil is compelling in light of the fact that it builds adrenaline and dopamine neurotransmission enough for these subjective points of interest, yet insufficient to make rapture and enslavement.
 
Albeit a few people are “non-responders” to modafinil, the vast majority record feeling a feeling of center and intellectual upgrade that advances a higher mental execution. 600 milligrams – so much modafinil pilots needed the US Air Force to spend 40 hours without sleep. At the same time, the speed of their reaction and accuracy remained almost at the same level.
 
In Maryland, the drug is used in long-term operations by police to improve concentration, and the Canadian Medical Society magazine claims that in the first-aid kit of cosmonauts on the ISS, modafinil is present in order to “optimize fatigue performance”.
 
Modafinil is a drug from the class of analeptics. The task of this class of drugs is to influence the centers of the medulla oblongata in order to stimulate the vital functions of respiration and circulation. In other words, modafinil invigorates. Modafinil, as well as Adderall and Ritalin, are most often prescribed for patients with attention deficit disorder and narcolepsy. But in the case of modafinil, it is often used as an amplifier of cognitive abilities. Modafinil” is a stimulator of a new generation, which is able to regulate a person’s wakefulness without any damage to sleep, which is sometimes necessary for a modern lifestyle.
The substance was first synthesized at the end of the 70s of the last century by the French pharmaceutical company Lafon Group. In December 1998, the FDA of America authorized the production and distribution of modafinil under the brand name Provigil. Modafinil , an alpha-1 adrenoreceptor agonist, enhances the release of dopamine in the central nervous system, and also enhances the release of GABA (gamma-aminobutyric acid).
 
Modafinil (known as Allertek, Provigil, Modalert) is a drug approved in most countries for the treatment of narcolepsy, uncontrolled episodes of daytime sleepiness caused by somatic (neurological) disorders. Modafinil suppresses the desire to sleep, increases physical endurance, improves memory, intelligence, and other parameters of mental activity. It is worth noting that the pharmacological profile of the drug has nothing to do with amphetamines, methylphenidate (ritalin) and cocaine.
modafinil structure
 
The uniqueness of modafinil lies in its ability to act only when necessary, as well as in the absence of side effects (anxiety, agitation, insomnia, “hangover” or “otkhodnyak“), which is usually pronounced when taking other “prescription stimulants”. Modafinil is not addictive, practically does not cause euphoria, reduces peripheral excitation of the nervous system and has little effect on blood pressure.
 
The drug can be used to maintain a clear mind during a long absence of sleep.
During clinical trials it was proved that the drug has a very high level of safety.

Benefits:

  • Modafinil provides a wakefulness effect without affecting other bodily functions.
  • Improves performance in working and number memory .
  • The stimulant increases the attention span .
  • Used by students and entrepreneurs as a brain doping tool .
  • Dose: 50-200mg 1x per day in the morning. Beginners start with 50mg .
  • The effect lasts between 12 and 24 hours .
  • Due to the development of tolerance of the body, modafinil should be used only sporadically . Maximum 3 times a week.
  • It works by increasing the concentration of various neurotransmitters in the brain.
  • It originated from the drug " Adrafinil " developed in 1970 .
  • The most common side effect (if any) is headache.
Most importantly, modafinil exceeds expectations at what it was initially intended to do: it builds attentiveness and readiness, and upgrades mental capacity in a restless state.

A subordinate of the noteworthy non-amphetamine stimulant adrafinil, modafinil is both quicker acting and more bioavailable than adrafinil and has been showcased as a different medication since the late 1970s. After broad testing, modafinil was affirmed by the US Food And Drug Administration for use as a narcolepsy treatment in the late 1990s.

As an eugeroic or alertness advancing specialist, modafinil has been appeared to viably avoid abundance daytime languor without upsetting ordinary evening time rest. This makes it an amazingly important treatment for individuals with narcolepsy or related rest issue, for example, obstructive rest apnea. It is additionally helpful for individuals whose employments expect them to be caution and dynamic during the evening when their circadian tickers are instructing them to rest. The US military has effectively utilized modafinil to help helicopter pilots remain caution all through supported activities.

It's imperative to comprehend that while modafinil upgrades alertness, it is anything but a long haul substitute for rest. In spite of the fact that modafinil can be utilized to remain wakeful through standard rest periods for a brief timeframe without causing a prompt difficult rest obligation, sufficient rest is significant for good wellbeing and psychological capacity. Numerous off-name clients who take modafinil as a nootropic report that they get the best subjective lift and most noteworthy nootropic impacts from modafinil when they are not restless.

Cognitive Effects:

Promoting wakefulness is only one of modafinil’s effects. It’s particularly good at enhancing cognition, both in healthy non-fatigued people‍ and in people experiencing sleep deprivation.‍ It is also proven to improve mental function for people with conditions that impair attention processing, such as cognitive decline, ADHD, or drug dependence.

Treatment of Other Conditions:

Research indicates that modafinil is comparable to amphetamine in the treatment of ADHD.‍ Though it is now sometimes used as an alternative to conventional stimulants for the treatment of adult ADHD, it is currently not approved as a treatment for childhood ADHD. Studies also suggest that modafinil is an effective treatment for both the fatigue and memory impairment related to multiple sclerosis.‍  Ongoing clinical trials are testing modafinil as a treatment for a broad range of conditions, including depression, schizophrenia, seasonal affective disorder, and nicotine addiction.

Neuroprotectant:

Interesting new research suggests that modafinil can actually promote brain health. It has antioxidant properties that can reduce the presence of damaging free radicals in the brain tissue, making it an effective neuroprotectant.‍

Impulse Control:

Modafinil has been shown to be an effective means of impulse control in a variety of situations, including alcoholism‍ and gambling addiction.‍
modafinil in news

The benefits of modafinil are manifold and have been researched extensively over the past decade. Partially, this is due to the military and government interest in modafinil as a tool for soldiers and pilots who engage in combat activity under sleep-deprived conditions.

According to multiple studies, there is a significant decrease in fatigue when using modafinil. Users that experience sleep deprivation or have hyperinsomnia find that their mental performance is heightened after using modafinil (or the downsides are negated). Another benefit of modafinil is with regard to general cognitive abilities. Modafinil can improve cognitive abilities, which are measured by reaction time , working memory , and other tests. While the benefits are less for non-sleep deprived individuals, it is obvious that healthy adults can still see cognitive benefits from using modafinil. One of the favorite uses for modafinil is attention, alertness, and concentration. While all of these are similar in their mechanisms as “wakefulness”, they are slightly different from a scientific perspective. The quantity of research literature shows that modafinil has a positive impact on all of these factors. One of the well known employments of modafinil is as an Adderall elective. When looking at modafinil versus Adderall, abstract encounters are not by any means the only information focuses.

Modafinil
Brain scan showing key differences between placebo brains and modafinil-treated brains

The military has used numerous logical examinations to see the distinction among modafinil and amphetamines. In one examination, military staff labored for 64 hours in a row utilizing either modafinil or amphetamine. Inside the two evenings without rest, the modafinil could keep a decrease in inclination and insight also to the amphetamine. In any case, modafinil is to a great extent considered more secure and more manageable than Adderall or amphetamines. In another examination, modafinil was utilized to treat methamphetamine addicts with extraordinary impact. It could enhance working memory and comprehension in patients who were experiencing fixation despite the fact that it didn’t positively affect response time. In this way, it may be a helpful Adderall withdrawal arrangement.

Modafinil
Averaged Positron Emission Tomography Images for After Placebo and After Modafinil

At long last, while thinking about that 11% of U.S. kids are right now taking amphetamine-based professionally prescribed medications, it is beneficial to perceive how modafinil thinks about for youngsters and ADD/ADHD. An investigation of youngsters utilizing modafinil for about a month and a half found a 48% enhancement in ADHD manifestations, (for example, distractedness, hyperactivity, and discernment).

How Modafinil Works

Modafinil’s belongings are comparable somehow or another to those of regular stimulants, however its novel components of activity separate it. In contrast to amphetamine, methylphenidate, and other focal apprehensive stimulants that incite alertness by general far reaching neuronal enactment, modafinil initiates neurons specifically, concentrating principally on the nerve center and amygdala.

While it is realized that modafinil tweaks the mind’s histamine, norepinephrine, serotonin, dopamine, and orexin frameworks, the exact systems of its activity have not been recognized as far as finding a solitary site of activity or real receptor official.

In any case, plainly modafinil’s impact on different imperative synapses is at the core of its strength, both as an eugeroic and as a nootropic. Mostly modafinil is taken to treat hypersomnia (pathological drowsiness) with narcolepsy.

Modafinil Sleep Case Study
Efficacy Measures Used to Assess the Effects of Modafinil versus Placebo in Patients with Shift-Work Sleep Disorder.

In the US, this drug is approved by the FDA for the treatment of sleep disorders associated with shift shifts. For example, in the US Air Force, this drug was used in several operations and is being studied for other purposes

Studies have shown that 600 mg of the active substance were able to maintain a concentration of pilots for 40 hours without sleep, but side effects in the form of dizziness and nausea appeared. Subsequent studies led to the fact that 300 mg of modafinil, divided into 3 doses, maintained a concentration of 27% from the baseline in pilots who were deprived of sleep for 37 hours. The side effects were minimal.

In a study with 88-hour sleep deprivation in the military, it was found that 400 mg of modafinil per day favorably affects the maintenance of alertness, but not enough to fully compensate for the lack of sleep. According to the journal of the Canadian Medical Society, modafinil was used by astronauts on the ISS to combat changes in circadian rhythms and reduced sleep quality.

Studies have shown that 600 mg of the active substance were able to maintain a concentration of pilots for 40 hours without sleep, but side effects in the form of dizziness and nausea appeared. Subsequent studies led to the fact that 300 mg of modafinil, divided into 3 doses, maintained a concentration of 27% from the baseline in pilots who were deprived of sleep for 37 hours. The side effects were minimal.

Orexin/Hypocretin

The wakefulness is mainly produced by the activation of orexin-1 and orrexin-2 receptors. Orexin influences vigility and regulates the energy balance in the central nervous system (CNS). The hormone-like peptide acts on sleep-wake behavior ; It is believed that a mutation in the gene that causes sleeping sickness narcolepsy Narcolepsy is caused due to lack of orexin and Modafinil works to make it perfect. The Modafinil acts with the neural system and increases the production of histamines in the brain, which boosts focus and alertness.

Much of modafinil's attentiveness elevating activity is owing to its activity on the cerebrum's orexin/hypocretin framework, which is situated in the nerve center and is in charge of controlling alertness, excitement, and hunger. The most widely recognized type of narcolepsy is caused by an absence of orexin, which modafinil is accepted to address by acting straightforwardly on orexin neurons. Invigorating these neurons likewise builds creation of histamines and other imperative synapses that are identified with attentiveness and sharpness.

Histamine

Increases the production of histamines in the body that helps the individual to stay awake for more extended periods of time. After administration of modafinil an increased histamine value in the hypothalamus (brain region) could be observed. - It is believed that this process is partly responsible for the wakefulness effect.

Though we for the most part catch wind of histamine in connection to sensitivities and nearby safe reactions, it likewise assumes a vital job in the direction of the rest/wake cycle. Modafinil's activity in the nerve center is accepted to raise histamine levels, contributing fundamentally to attentiveness and readiness.

Dopamine

Unlike the other drugs that increase the release of dopamine quickly, modafinil blocks the receptors and allows a slow and steady release of Dopamine on the receptors of the synapse system, making it work properly without feeling extremely euphoric at a particular moment and utterly exhaustive at the other.

Modafinil raises the dopamine concentration in the nucleus accumbens (part of the foror brain) and striatum (tein of the cerebrum).An essential synapse related with the upgrades/remunerate reaction, dopamine can enhance temperament and increment inspiration and core interest. Dissimilar to amphetamines and different stimulants which straightforwardly invigorate dopamine discharge and increment dopamine levels in an extremely fast and very intensified way, modafinil works all the more step by step by hindering the receptors that expel dopamine from the neurotransmitters, which adequately lifts the measure of dopamine accessible for prompt use in the mind.

This steady and to some degree roundabout activity on the dopamine framework is an essential component of how modafinil functions since it decreases the "surge" kind of elation that is related with compulsion.

Norepinephrine

The effect of Modafinil toches the norepinephrine system of the human brain also. This makes the human mind to stay alert and awake. Modafinil is accepted to expand the accessibility of norepinephrine, a stimulant synapse that advances attentiveness and builds readiness. The correct means by which modafinil builds the accessibility of this stimulant synapse is vague, however it might be identified with modafinil's activity on the orexin framework and dopamine receptors.

Glutamate

Glutamate in the brain is responsible for improving focus and memory and overall cognitive functioning. Modafinil allows the neurotransmitters to send a signal and glutamate is released in the required amount. The ultimate release helps in supporting the cognitive function improvement, effectiveness, and productivity.

Modafinil raises dimensions of glutamate, the cerebrum's important excitatory synapse, by animating the extracellular arrival of glutamate in the nerve center. Glutamate assumes a critical job in subjective capacity, and this expanded accessibility assumes an imperative job in modafinil's nootropic impacts, from expanded memory to enhanced concentration and even cerebrum pliancy.

In spite of the fact that not everything about modafinil's instruments of activity is totally seen, over 40 years of broad research have given important bits of knowledge on its belongings.

Impacts in Comparison to Amphetamines

A recent report confirmed that modafinil is more powerful than methamphetamine at hindering the rest drive, regardless of the way that modafinil expanded engine movement just marginally while methamphetamine created significant increments in engine activity.‍ A similar report likewise exhibited that modafinil delivered more combined times of alertness than methamphetamine. Strangely, modafinil has been appeared to reestablish typical dimensions of learning capacity in methamphetamine addicts.‍ While modafinil compulsion is perceived as a probability, it is generally accepted to have essentially bring down habit hazard than amphetamines‍ and has even been proposed as a treatment for methamphetamine and cocaine addictions.

Impacts on Exercise and Sports Performance:

Modafinil has been appeared to enhance sports and exercise execution, to a great extent by altogether expanding the time before sentiments of depletion are experienced and decreasing the view of fatigue.‍It was added to the World Anti-Doping Agency's rundown of restricted substances in 2004.

Consequences for Cognitive Abilities

Decades of research bolster the possibility that modafinil results in quantifiable enhancement in a wide exhibit of psychological capacities, going from working memory and liquid insight to both spatial and verbose memory, design acknowledgment, official capacity, and execution on undertakings that require more elevated amount thinking in solid adults.‍ Some examinations recommend that modafinil's belongings might be most set apart among low-performing subjects.‍Clinical preliminaries affirmed that modafinil enhances disposition in sound subjects however may result in anxiety.‍

The drug is often used by American students during sessions, as well as by people who want to increase their productivity. In the US, modafinil is sold in pharmacies, but in Russia it cannot be bought in this way – the drug did not register with the Ministry of Health of the Russian Federation and is illegal. 

Scientists and doctors agree that the drug has almost no side effects. University of California psychiatrist James McGough (James McGough) said that the consequences of an overdose of modafinil are the same as with an overdose of coffee – nervousness and abdominal pain. According to him, the drug is not addictive. However, he explains:

If you stop taking modafinil, there will be no painful side effects. But having experienced its influence and the absence of side effects, many do not see the point in refusing the drug.

It is impossible to find statistics about those taking the drug for obvious reasons – it is not typical for people to admit to taking doping. Even if it is harmless. In 2011, the BBC conducted an anonymous survey, asking readers if they accept cognitive enhancers, in particular modafinil. 38% of respondents answered “Yes.” Of these, 40% said they bought the drug online, and 92% said they would try it again. In total, about a thousand people took part in the survey. Reviews about the drug ranged from neutral to admiring. Some scientists still do not advise taking modafinil. The reason is simple: if you feel not enough energy or vigor in yourself, then why increase their level at the expense of drugs? Modafinil can be compared to taking painkillers – if you have a headache for a week, you will not drink pills, but try to find out the cause of the disease.

modafinil bbc study

Barbara Sahakian, a professor at the University of Cambridge, is more loyal to the drug. Her team began to study its effects on Alzheimer’s and Parkinson’s patients, and then conducted several tests on healthy people. Their study proved that surgeons who were deprived of sleep for a long time did a better job, taking modafinil. Professor Sahakyan recommends using the drug to those whose work is stressful or causes stress at a particular moment.

Image result for quote about modafinil

Chemical Structure & Synthesis

Synthesis of modafinil: Benzhydrol is chloroacetic acid and thiourea to 2- (diphenylmethylthio) -acetic implemented which over acid chloride in acid amide will be converted.

Image result for modafinil structure

The target compound results from the subsequent oxidation with hydrogen peroxide .

Stacking Of Modafinil

Modafinil and Ashwagandha: 

Basic for making you lose and boosting imaginative reasoning. Ashwagandha is an antiquated herb valuable for treating nervousness, stress, weakness, and torment. The stack impact of Modafinil and Ashwagandha has turned out to be extremely useful. The outcomes enable the person to work beneficially for the duration of the day and battle the uneasiness levels all the more effectively given by the modafinil. Ashwagandha enables the body to isolate from the outside condition and give alleviation from stress. The Indian herb impacts are gradual. It is extraordinary compared to other blends to be brought with the Modafinil.

Modafinil and Bacopa: 

Bacopa is an Indian plant which treats memory issues. The appropriate measure of Modafinil Bacopa stack upgrades human reasoning force turning into a solid mix for learning, maintenance and retention. Bacopa Monnieri is the ideal memory supplement and furthermore a fantastic solution for symptoms of modafinil.

Modafinil and Caffeine:

 This combination is very famous almost in every part of the world. The dose of Modafinil can be taken early in the morning and coffee can be consumed later to balance the effects of the stack.

This way the Modafinil helps in increasing the brain performance and the overall productivity and the caffeine helps in the wakefulness and energy boost. The effect of Modafinil lasts longer on the brain, whereas caffeine is a short-term effector. This makes them a right combination of nootropic stack.

The disadvantages Modafinil Caffeine stack is the diuretic effect on the individual. It can cause dehydration and a sense of jitter. This must be treated by taking the dose on proper time.

Modafinil and Piracetam: 

This is acetylcholine drug that helps in increasing brain activity, blood flow and oxygen consumption in the body. The Racetams are responsible for expanding the mood senses and focus improvement.

The only disadvantage of the combination is that it can make the body feel discouraged and utterly exhausted at the end of the day. With the help of Choline addition to the stack, this disadvantage can be converted into an advantage.

Modafinil and Noopept: 

Noopept is known as a cognitive enhancer. It should be consumed with total care in small doses. It is more effective and powerful in comparison with the Piracetam. It helps in strengthening the learning capabilities, thinking skills, and focus. But studies also point out the fact that Noopept can lead to apoptosis and oxidative stress.

When the two nootropics are combined the user experiences increased motivation levels, improved memory recall, alertness and mental clarity with anything the user does.

This consumption is occasionally advised when the individual needs large focus during the work. It is essential to keep the dosages small to start with and build them up as necessary as it can lead to complete exhaustion of the body.

Modafinil and Phenibut: 

Phenibut is a “smart pill” that is used for anxiety, fear, and fatigue, also to prevent fogginess and depression. Modafinil has side effects like anxiety and insomnia, and these side effects are well managed by the Phenibut. This makes the perfect combination.

The benefit is that the person can work during the day and sleep in the night without facing any problems. Modafinil Phenibut stack gives tolerance power and becomes perfect for social engagements. It is advisable to use this drug once a week, but always consult with your physician.

Modafinil and L-Theanine: 

This combination has mixed reviews from the nootropic stack fans. While many say that the combination is not that effective, some are impressed by the effects on cognitive function.

L-theanine is a component that is found in small proportions in the tea leaves. The stimulant helps in relaxation of the body. Due to a characteristic of the L-Theanine, the body goes into a slow pace, and the level of effectiveness is barely visible.

Some of the side effects of consuming Modafinil is that the individual starts feeling jittery and anxious. L-Theanine is a component which really helps in fighting these side effects. Modafinil L-Theanine stack is perfect for boosting your brain while staying composed and collected.

Modafinil and Choline: 

Consuming Modafinil Choline stack is known to create wonders. It is capable of boosting the mobility of the brain synopsis network. Choline is an essential nutrient for the development of, and neurotransmitter production in the brain is present in many plants and animal organs. Modafinil is improving the cognitive abilities of the individual along with the productivity.

The combination is so helpful that many receivers report that it helps to fight a migraine and headaches caused by the Modafinil. The problem of feeling lazy after having lunch or dinner due to the ingestion period is resolved with the help of this stack. The Choline also expands the activity levels of Modafinil and helps in improving its effects.

Risks, side effects & toxicity :

Here at BrainsOnTrial we studied some side effect results about Modafinil. Modafinil is very safe compared to Adrafinil . The chance of side effects such as abdominal pain, skin irritation, anxiety, and liver damage (with chronic ingestion) is very low .

As long as the dosage is not exaggerated, and reasonable amounts are taken, no side effects should occur; However, these are not completely ruled out.

Clinical Trials: 

Patients reported the following (unwanted) side effects

  • a headache
  • weight loss
  • insomnia
  • Decrease in the feeling of hunger
  • Accelerated pulse
  • nervousness
  • skin rash
  • dizziness
  • Dry mouth
  • skin rash
  • nausea
  • psychosis
  • Suicidal thoughts
  • delusions

What is a Typical User Experience?

Whether you talk to users in person or read various Modafinil reviews, the user experience is similar for most people. Many people with experience using it refer to it as a “limitless pill.” Users of this nootropic often state that Modafinil is similar to what Bradley Cooper experienced in the movie “Limitless.” Of course, the movie moves much faster than real life and most people will not multiple languages in a matter of weeks. However, the cognitive enhancements associated with this drug could help users to focus on what they are working on far more than what they are used to. This could make it easier to learn new things and experience a distinct increase in overall productivity.

Many users start with half a pill so that they can better ease into the effects of Modafinil. Many report that within 15 to 30 minutes, they start to notice an invigorating effect that makes them feel awake and alert. However, there is also a sense of clarity and calmness and not the more powerful sensation of euphoria.

Users report that the things that distracted them in the past were no longer distracting. Their brain seemed to keep its focus solely on the task at hand. They remained motivated to keep tackling their to-do list and everything seemed to be clear. They were not forgetting things and found it easy to remember immediate things without having to write them down.

Users say that it was easy to stick to a single task at a time. This allowed them to get more done each day. Even the more comprehensive and difficult tasks were easy to keep their focus on.

Adult students who took Modafinil before class stated that it was easy to take notes and keep their focus on the lecture taking place. When they needed to complete homework or study, they were able to focus on the task and not get distracted even if they were in a noisy environment, such as a student center or a shared dorm room.

Many people are simply overworked and do not get adequate sleep each night, so they turn to nootropics like Modafinil to give them sustained energy. Those taking it for this purpose report a gentle, but effective, boost in energy levels that lasted all throughout the day. They did not experience negative effects, such as feeling anxious or jittery, like they do when utilizing caffeine for wakefulness.

Does Modafinil Promote Weight Loss?

Modafinil is often touted as an effective weight loss remedy. In fact, some research shows that it might be an effective treatment for those suffering from food addiction. This is largely due to the drug working to reduce impulsivity so that people can make more logical and controlled decisions.

One study that looked at the effect of Modafinil on food addiction discovered that the patients who took Modafinil had a significant decrease in their overall impulsivity as it relates to food. This might help people to gain greater control over their diet so that they are able to lose excess weight. This study, along with several others that were controlled and often looked at the benefits of Modafinil as it compared to other food addiction drugs and a placebo, show great promise when it comes to using Modafinil as an effective weight loss drug. It could help people to make better dietary decisions so that they are able to lose weight in a healthy and natural way.

Can You Use Modafinil for ADHD?

ADHD is a condition that is most commonly associated with children, but it affects adults too. It makes it difficult to control impulses, concentrate, avoid distractions and sustain attention. Those with the condition also tend to experience bouts of hyperactivity. The action of Modafinil in the body is similar to that of the simulants that are most often prescribed to treat this condition. Researchers have found the following concerning Modafinil for ADHD:

  • Compared to a placebo, the short-term efficacy of Modafinil was superior
  • The drug was shown to act on a number of attention system which would lead to improved attention span in those taking the drug
  • Compared to the placebo used in the study, Modafinil showed to have a similar tolerability and safety profile

How Does Modafinil Compare to Adderall?

Modafinil vs. Adderall is a common debate right now. One controlled, double-blind study showed that compared to conventional stimulants like Adderall, Modafinil was a viable alternative. Another study found that this drug would be a good choice for those who did not favorably respond to Adderall or other conventional ADHD drugs on the market.

Many doctors are afraid to treat ADHD in adults and it is estimated that approximately 75 percent of adults who have this condition do not ever get an accurate diagnosis. Because of this, many turn to nootropics to improve their attention, motivation and overall cognitive abilities. Modafinil is one of the most popular nootropics due to its ability to promote sustained energy with the cognitive-boosting effects.

Is Modafinil Legal?

In the form of a nootropic, it is legal to purchase this in most areas of the world. You can often buy Modafinil online in various nootropic forms, such as Adrafinil. This is the most popular nootropic form and it is a compound that is a precursor to Modafinil. Once the liver processes Adrafinil, it becomes Modafinil.

Make sure that you seek out the best place to buy Modafinil so that you can be confident that you are getting a superior product. Read reviews and look into the company to make sure that they have a solid reputation for producing high-quality products.

You can see that Modafinil is one of the nootropics on the market that shows a lot of promise in helping people to be more productive. As with all supplements and drugs, it is a good idea to consult a doctor before using or buying Modafinil online to ensure optimal safety. You must also ensure that you are using it at the recommended dosage to ensure the most benefits and the lowest risk of potential side effects.

Interactions:

Modafinil can reduce the effects of some medications by speeding their breakdown. These include: itraconazole, ciclosporin, temazepam, amitriptyline, and erythromycin.

If blood-thinning agents such as aspirin or warfarin are taken, you should regularly check your blood clotting.

The effect of modafinil could be mitigated by birth control pills.

Pregnancy:

Modafinil should not be taken during pregnancy. There is no research on the use during lactation, also here the intake is not recommended.

Toxicity & lethal dose:

In rats, an average lethal dose of 1250 mg / kg was found.

In one study, human participants were given daily doses of up to 1250 mg and single maximum doses of up to 4500 mg.

There was no life-threatening effect.

Observable side effects included: anxiety disorders, confusion, diarrhea, aggression, palpitations, sleep disorders, and nightmares.

There are no fatal overdoses known with modafinil; The lethal dose (when taken orally) in humans is uncertain, but it is considered to be higher than that of caffeine.It is reported a suicide attempt with 4500 mg, where the patient survived without long-term impairments; Temporary side effects were nervousness, nightmares and nausea. While the long-term effects of taking this drug are still relatively unknown, researchers at Harvard and Oxford universities have conducted a thorough study on Modafinil, and concluded that its short-term consumption appears without danger or risk of addiction, reports the Guardian .

Easily found in the United States and across the Channel, where it is prescribed under the name of Provigil.

Conclusion:

Modafinil is an amphetamine derivative classified in narcotics. It is one of the exceptional products requiring a hospital prescription. A check-up with a cardiologist is mandatory before the first shot. The side effects can be important especially on the cardiovascular sphere. Banishing Modafinil by presenting it as an intellectual dopant relevant to healthy people is surprising to say the least. This has the gift of making jump the patients who they, would be good to consume this type of molecule.

The effects of the prolonged consumption of Modifinil remain unknown today. Results of the combinations listed above may vary due to the individual. The body and genetic mechanism are different for all of us.  A dose for one is not suitable for the other. Always consult your physician before consuming any of the supplements. Also be aware of all side effects.

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