Modvigil is a generic version of modafilin, a cognitive enhancing drug from the afinil family. Modvigil is used to improve wakefulness in adults who suffer from excessive sleepiness associated with narcolespsy, shift work disorder, or obstructive sleep apnea.
Blister packs of Modvigil tablets
Attribution: Flickr/ Streamishmc
Modvigil, or modafinil, has a variety of different reactions in the brain and these reactions produce wakefulness and cognitive enhancing benefits.
This drug is also popular with students, business owners, and creative professionals because of its ability to improve concentration and productiveness. Because of this, it is also known as a “study drug.”
In the United States, Modvigil is known as Provigil and is made by the American brand Cephalon Inc.
Buy Modvigil: to buy modvigil online you have to look for online pharmacy that is offering this med based on prescription.
Benefits of Modvigil
Modvigil is a cognitive stimulant but unlike other drugs in the afinil family, it produces more subtle effects. The drug works through the orexin system in our brain and increases neurotransmitters like dopamine and norepinephrine.
The orexin system is responsible for regulating our sleep cycle. Dopamine, on the other hand, is associated with focus, emotion, and the reward center responsible for controlling our habits and motivations.
Modvigil helps users stay alert longer while they are studying, resulting in fewer breaks and increased productivity. Because of this, many people take it to get rid of writer’s block, cram for tests, and finish monotonous and tedious tasks more quickly.
Modvigil Dosage and Administration
Dosage in Obstructive Sleep Apnea and Narcolepsy
The recommended dosage for this drug is 200 mg taken once a day for patients who suffer from obstructive sleep apnea and narcolepsy. Two Modavil 200 mg tablets have been given as a single dose and have been well-tolerated although there is not enough evidence to suggest that the double dosage provides any additional benefits to the patient.
Dosage for Shift Work Disorder
The recommended dosage for patients with shift worker disorder is 200 mg taken orally once a day about 1 hour before their shift starts.
Dosage for Patients With Severe Hepatic Impairment
Patients who have severe hepatic impairment need to reduce their dosage of Modvigil tablets by half that recommended for patients with healthy livers.
Dosage for Geriatric Patients
Patients who are over 65 years of age need to be closely monitored if they are given a dose of Modvigil. In older patients, the elimination of the drug and its metabolites may be reduced as a natural consequence of aging. Therefore, it is recommended that their dosage be lowered and the patients be monitored.
Dosage for Expectant or Nursing Mothers
There are no well-controlled studies which can show the effect of Modvigil on the health of a pregnant or nursing mother. In some cases, intrauterine growth restrictions and spontaneous miscarriages have been linked with the use of this med. It is also unknown if the drug is passed into breast milk. Therefore pregnant and lactating women should consult their doctor first before using Modvigil.
Dosage for Pediatric Patients
Modvigil has not been established as safe and effective for this population. Adverse reactions like serious skin rash, including Stevens-Johnson Syndrome (SJS) and erythema multiforme major (EMM), have been linked with the use of Modvigil in the younger population. Hence, infants and children should not be administered this drug.
Adverse Reaction of Modvigil
For patients who have been prescribed Modvigil by doctors should understand that the drug poses more benefits than the risks of side effects. Many people who have Modvigil do not experience any sort of side effects.
Very serious side effects of this drug are quite rare and you need to consult a doctor if you experience these. Some noticeable side effects include:
- Headache and dizziness
- Allergic rashes
- Swollen nymph nodes
- Itching and swelling of the face, tongue, and throat
- Severe dizziness
- Breathing issues
- Angioedema and anaphylaxis reactions
- Persistent sleepiness
- Chest pain
- Back pain
- Urine abnormality
- Taste prevention
Modvigil Interactions with Other Drugs
Effects of Modvigil on CYP3A4/5 Substrates
There are many drugs that may be deactivated or exhibit reduced clearance by Modvigil, including CYP3A4/5 Substrates, resulting in reduced systemic exposure. Adjustment of dosage of these drugs should be considered if they are taken in conjunction with Modvigil.
Additionally, the efficacy of steroidal contraceptives may be reduced while the patient is taking Modvigil and will remain so till one month after discontinuing Modvigil. Alternative methods of contraception are recommended for patients who have been taking steroidal contraceptives.
Blood levels of immunosuppresant medication like cyclosporine may be reduced when used in concomitantly with Modvigil tablets. Adjustment of dosage is recommended in this case.
Effects of Modvigil tablets on CYP2C19 Substrates
Conversely, there are many drugs that may show prolonged elimination when used with Modvigil due to the inhibition of metabolic enzymes. This results in higher systemic exposures. Therefore, levels of drugs containing CYP2C19 substrates like selective serotonin reuptake inhibitors and tricyclic antidepressants, may be increased if taken in conjunction with Modvigil. Reducing the dosage for these drugs may be necessary for such drugs.
Effects of Warfarin
When taking blood-thinning medicines like Warfarin in conjunction with this med, the prothrombin time (a test used to detect bleeding or clotting disorders) and INR (international normalized ratio) must be considered.
Effects of Monoamine Oxidase Inhibitors
Taking Modvigil with MAOIs can lead adverse effects like chest pain, high blood pressure, severe headaches, and high body temperature. People who take Modvigil should not take MAOI within 14 days of using the drug.
Clinical trials show that patients who have been given 5 to 8 times the recommended dosage of Modvigil 200 mg have not experienced any unexpected or life-threatening effects. However, there were many side effects reports including agitation and excitation, insomnia, aggressiveness, confusion, tremors, nausea, diarrhea, sleep disturbance, and moderate elevations in hemodynamic parameters.
No specific antidote exists for this med and patients who overdose on this drug should be closely monitored, especially their cardiovascular behavior.
Where to Buy Modvigil
This drug has been classified as a IV controlled substance in the United States and Australia since it offers medicinal benefits, but with potential for abuse.
Because of the ambiguous legal status of Modvigil, the drug cannot be bought in stores based outside of the United States, Canada, Europe, and Australia. However, you can buy Modvigil from online vendors in India since the country doesn’t classify Modvigil as a prescription drugs.
It is a good alternative for cognitive enhance since it is less stimulating than others drugs in its family and has fewer side effects. It is also cheaper than other drugs and the risk of accidental overdose is low.